Neoplastic Mimics in Soft Tissue and Bone Pathology by Jason L. Hornick MD PhD Vickie Y. Jo MD

Author:Jason L. Hornick, MD, PhD,Vickie Y. Jo, MD
Language: eng
Format: epub
Publisher: Springer Publishing Company, Inc.
Published: 2016-11-05T11:08:00+00:00

FIGURE 7.1Neurofibroma. Tumor cells have ovoid and spindled, often comma-shaped nuclei, with abundant interspersed collagen fibers.

FIGURE 7.2Schwannoma characteristically shows varying hypercellular and hypocellular patterns of spindle cells with ovoid nuclei and palely eosinophilic, fibrillary cytoplasm. Clusters of lipid-laden histiocytes are common.

TRAUMATIC NEUROMA

Reactive lesions such as traumatic neuroma are rarely confused with malignant neoplasms, but may occasionally show morphologic overlap with benign nerve sheath tumors. Traumatic neuromas typically develop in response to injury, most commonly amputation or laceration on the extremities. Lesions show disorderly organization of normal nerve sheath components embedded in a collagenous stroma, with a variable admixture of nerve fibers, Schwann cells, and perineurial cells (Figure 7.3). In the absence of clinical history, traumatic neuromas may be mistaken for a benign nerve sheath neoplasm, such as a plexiform neurofibroma or schwannoma depending on the histologic appearances and most prominent components.

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